Drug and Therapeutics Bulletin 2008;46:29-32; doi:10.1136/dtb.2008.03.0009
Copyright © 2008 by the BMJ Publishing Group Ltd.
Depression, antidepressants and heart disease
Relevant BNF section: BNF 4.3
Around 1 in 5 people with coronary artery disease has major depression and the prognosis in heart disease is worse in those who are also depressed.1 Many antidepressants have unwanted cardiovascular effects, so choosing between them may not be straightforward in patients with heart disease. Here, we consider whether any of the commonly used antidepressants are more or less likely to exacerbate heart disease and whether treatment for depression affects cardiac outcomes.
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