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Analeptics in ventilatory failure: doxapram

Abstract

Modern management of ventilatory failure (carbon dioxide retention with hypoxia) by controlled continuous administration of oxygen in low concentration will usually prevent serious depression of ventilation in patients with acute exacerbations of chronic respiratory disorder. Few authorities would now rely on any ventilatory stimulant to prevent CO2 narcosis produced by worsening of the patient’s condition or by oxygen administration.

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