Tofenacine (Elamol - Brocades) has been introduced for the treatment of depression, particularly in elderly people. It is a major metabolite of orphenadrine (Disipal) and was developed as an antidepressive drug after mood-elevating effects had been claimed with orphenadrine given to patients with Parkinson’s disease. Motival (Squibb) is a combination of fluphenazine (Moditen) (0.5 mg) with nortriptyline (10 mg), and is promoted primarily for the treatment of anxiety combined with depression in general practice.
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