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Baclofen for spasticity

Abstract

Baclofen (Lioresal - Ciba) is a chlorophenyl derivative of gamma-amino butyric acid (GABA) which occurs naturally in the brain and spinal cord and is probably an inhibitory neurotransmitter substance there. Since it has a similar inhibitory effect it has been tried in patients with muscle spasticity due to lesions in the pyramidal tract.

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