Clotrimazole (Canesten - Bayer), an imidazole derivative was first synthesised in 1967.1 It is active against many medically important fungi and yeasts and is available as a cream or as pessaries; an oral preparation is under trial. Care should be taken to distinguish clotrimazole from co-trimoxazole (Septrin - Burroughs Wellcome; Bactrim - Roche), a totally unrelated drug.
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