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Drugs for acute pancreatitis: aprotinin and glucagon

Abstract

Pancreatitis has been treated since the late 1950’s with agents that suppress pancreatic secretion or inhibit the released enzymes. Five years ago1 we concluded that aprotinin (Trasylol - Bayer) had not been shown to offer definite benefits. A subsequent trial of this substance2 was difficult to assess because of variability among patients selected, of dosage regimens and of other treatment given. One recent trial has overcome some of these problems.3 Glucagon (Lilly) has also now been used in the treatment of acute pancreatitis.4 5

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