Obesity, its management, and anorectic drugs, have been discussed previously.1 In general our conclusion was and still is that anorectic drugs are better avoided where possible. The success of any weight-reducing regimen depends on reduction of calorie intake: anorectics can help the patient to accept the diet. At present two groups of anorectics are available: non-fluorinated amphetamines such as phentermine (Duromine) and diethylpropion (Apisate; Tenuate)2 which can produce euphoria and are occasionally abused,* and fluorinated amphetamines such as fenfluramine (Ponderax)3 which can induce unacceptable drowsiness during use, and depression during use or after withdrawal.
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↵* Phenmetrazine (Preludin - Boehringer Ingelheim), a non-fluorinated amphetamine, was withdrawn from the UK market in 1972 on account of abuse, but it is still sold in the USA, Canada and elsewhere.
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