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Dacarbazine (DTIC) in malignant melanoma

Abstract

Malignant melanoma usually starts in the skin. Its primary treatment is wide excision with grafting of the wound. Most surgeons believe that involved lymph nodes are best removed before giving radiotherapy, chemotherapy or immunotherapy. Since melanoma is relatively insensitive to radiation and established cytotoxic drugs, the outlook for patients with metastatic disease is very poor.

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