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Oxpentifylline (trental) in peripheral arterial disease

Abstract

Vasodilators are disappointing in the treatment of peripheral vascular disease. There is little evidence that they either increase blood flow or improve symptoms.1 Oxpentifylline (Trental - Hoechst) is a dimethyl xanthine related to caffeine, theobromine and theophylline. It is a weak vasodilator, but the maker claims that it also reduces blood viscosity which is increased in patients with peripheral vascular disease.2 3

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