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Pizotifen for migraine prophylaxis

Abstract

Pizotifen (Sanomigran - Wander) is structurally related to cyproheptadine, and has strong antiserotonin, antihistaminic, anti-tryptamine and anticholinergic actions.1 It is unrelated to simple analgesics, ergotamine, clonidine and propranolol.2 Methysergide (Deseril), another serotonin antagonist which is otherwise unrelated, can prevent migraine3 and therefore pizotifen has also been assessed as a prophylactic against migraine.

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