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Disopyramide for arrhythmias

Abstract

Disopyramide is an antiarrhythmic agent which the manufacturers claim to be effective in controlling both atrial and ventricular arrhythmias; recent promotion particularly emphasises the latter. It is marketed for oral use as the base (Rythmodan - Roussel) and as the phosphate (Norpace - Searle), but these preparations do not differ clinically and represent another example of pseudo-competition.1 For i. v. use Rythmodan is also marketed as the phosphate, no preparation of Norpace for i. v. use is available. When we discussed the drug four years ago2 there was insufficient evidence to recommend disopyramide for clinical use.

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