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Physical dependence on benzodiazepines?

Abstract

Benzodiazepines (such as chlordiazepoxide, e. g. Librium; diazepam, e. g. Valium) are the most widely prescribed and effective group of anti-anxiety drugs.1–3 Not only are they effective in reducing anxiety, they are safer in overdose than most other anti-anxiety agents. Furthermore, they carry a much smaller risk of dependence than barbiturates or meprobamate.4 Nevertheless dependence may supervene at high dosage taken for a long time.5–12

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