Purified porcine insulins were developed to reduce the immunogenic properties of conventional insulin. About 95% of diabetics who use standard beef insulin develop insulin antibodies within the first 12 weeks of treatment.1 These antibodies may increase the daily insulin requirement and slow the hypoglycaemic action because active insulin may be only gradually released from the antigen-antibody complex. Suggestions that the antibodies also increase the incidence of long-term diabetic complications2–4 are not widely accepted.
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