Hypertension can be controlled by reducing cardiac output or peripheral resistance or a combination of both. Diazoxide (Eudemine), hydralazine* (Apresoline) and minoxidil all reduce peripheral resistance by direct arteriolar vasodilatation, without sympathetic blockade. They all therefore cause a rise in cardiac output, and a compensatory tachycardia through reflex baroreceptor activity. This increase in cardiac output tends to restore the blood pressure and is associated with palpitations; both can be reduced by using these drugs with a β-blocker whose hypotensive effect is additive.
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.