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Ketoconazole - an antifungal drug for oral use

Abstract

Ketoconazole (Nizoral - Janssen) is a new antifungal agent. Like the other imidazoles with antifungal activity such as miconazole,1 clotrimazole2 and econazole,3 it acts by inhibiting fungal cell-membrane synthesis.4 It is well absorbed and exerts a systemic effect; it is thus suitable for oral administration.

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