Metoprolol - A second slow-release preparation of metoprolol, Slow Lopresor (Geigy) has just been marketed. We had cited a study which indicated to us that one 200mg tablet of Slow Lopresor did not adequately block β-receptors for 24 hours (MJ Kendall et al, Eur J Clin Pharmacol 1980; 17: 87). The manufacturer has now shown us more recent evidence that one such tablet maintains some measurable β blockade over 24 hours, and is comparable with Betaloc SA.
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