Abstract

Many antispasmodic and anticholinergic drugs have been shown to reduce motility and secretion in different parts of the digestive tract, but in doses large enough to be effective these drugs invariably produce side effects. Oxyphencyclimine (Daricon - Pfizer) inhibits gastric secretion in animals without the peripheral anti-cholinergic effects seen with comparably effective gastric anti-secretory doses of other anticholinergic drugs tested. ¹ Studies in man suggest that oxyphencyclimine has a selective action on the stomach, ² that it can relieve symptoms of duodenal ulceration, ³ and that it has a prolonged action.