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Co-trifamole (co-fram)

Abstract

Co-trifamole (Co-Fram - Abbott) is a new combination of a sulphonamide, sulphamoxole, and trimethoprim for oral use. It is similar to co-trimoxazole (sulphamethoxazole + trimethoprim; various brands) and co-trimazine (sulphadiazine + trimethoprim; Coptin),1 which has recently been withdrawn from the UK market. The manufacturer claims co-trifamole to be effective in lower dosage and therefore with fewer dose-dependent adverse effects.

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