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Medical treatment of gallstones: ursodeoxycholic acid

Abstract

We discussed the dissolution of gallstones with chenodeoxycholic acid (CDCA) (Chendol - CP Pharmaceuticals; Chenofalk - Thames) five years ago.1 Now a second drug, ursodeoxycholic acid (UDCA) (Destolit - Merrell; Ursofalk - Thames) is available for the same purpose. Like CDCA it is given by mouth to dissolve non-calcified cholesterol gallstones in the gallbladder. Several potential advantages are claimed for UDCA; what is its place in treatment?

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