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Non-sedative antihistamines: ▾ terfenadine and ▾ astemizole

Abstract

Terfenadine (Triludan - Merrell) and astemizole (Hismanal - Janssen) are two chemically unrelated oral H1-receptor antihistamines marketed recently for the relief of allergic rhinitis, conjunctivitis and other manifestations of histamine release, such as urticaria. Both are claimed to be free of the usual anticholinergic and CNS effects, especially sedation, which limit the use of other H1 antihistamines. If this major claim justified?

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