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Sustained-release theophylline preparations

Abstract

Oral theophyllines have long been used to treat airway narrowing in patients with asthma and chronic bronchitis.1 Their popularity waned when effective local treatment became available with inhaled β2 stimulants, and later with the anticholinergic drug ipratropium bromide. They are now being used more widely again since the advent of sustained-release (s/r) preparations, several of them strongly promoted. When are they worth using?

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