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Cancer chemotherapy: ▾ carboplatin v cisplatin

Abstract

Carboplatin (Paraplatin – Bristol Myers) is an analogue of cisplatin, intended to offer equal efficacy with less toxicity. Cisplatin is very effective in the treatment of testicular and ovarian cancer and several other malignancies, but it is also very toxic. It causes peripheral neuropathy, auditory and renal damage, severe vomiting and mild bone marrow suppression.1,2 in early clinical studies, carboplatin appeared much less nephrotoxic and neurotoxic than cisplatin, and less emetic.3 How has it turned out on further evaluation?4

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