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▾ Terodiline and oxybutynin in detrusor instability

Abstract

In normal micturition autonomic cholinergic nerves initiate detrusor muscle contraction, which is followed by relaxation of the urinary sphincter. Involuntary detrusor contractions can occur in neurological disease; ‘detrusor instability’ describes involuntary contractions where there is no underlying neurological cause. Symptoms of detrusor instability are urinary frequency, urgency and sometimes incontinence. Terodiline (Terolin - KabiVitrum) and oxybutynin are two of the newer drugs being used in its management.

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