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Choosing between oral amoxycillin, pivampicillin and ampicillin

Abstract

Amoxycillin and pivampicillin are both structural modifications of ampicillin. Amoxycillin is itself active but pivampicillin is a prodrug* which is hydrolysed to ampicillin in the body.1 Thus the antimicrobial spectrum and activity of pivampicillin and ampicillin are identical; those of amoxycillin differ little except in typhoid, where amoxycillin is better. Ampicillin is minimally more active than amoxycillin against Haemophilus influenzae.

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Footnotes

  • * Bacampicillin and talampicillin are other less used prodrugs of ampicillin.

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