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Gemeprost for second-trimester termination of pregnancy

Abstract

During labour endogenous prostaglandins are involved in the process of softening the cervix. Gemeprost, an analogue of prostaglandin E1, is used as a vaginal pessary (Cervagem - May & Baker) to soften and dilate the cervix before vacuum aspiration of first-trimester pregnancy.1 It can now also be used for medical termination of pregnancy in the mid-trimester.

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