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Do drugs help intermittent claudication?

Abstract

Many drugs are promoted for the treatment of intermittent claudication: cinnarizine (Stugeron Forte), cyclandelate (Cyclospasmol), naftidrofuryl (Praxilene), inositol nicotinate (Hexopal) and oxpentifylline (Trental); two other nicotinic acid derivatives, Bradilan and Ronicol, are licensed but not promoted. In 1988 the Committee on Review of Medicines deleted claudication as an indication for isoxsuprine (Duvadilan) from the product licence because evidence of efficacy was insufficient, but the CRM has been very slow to review the efficacy of the other drugs. Is there evidence that any of these drugs improve walking distance more than placebo?1,2,3

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