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Three new non-sedative antihistamines: worth keeping an eye open for

Abstract

Oral antihistamines are used to relieve symptoms in allergic rhinitis, conjunctivitis, urticaria and eczema. Traditional H1 receptor antagonists have sedative, and in some cases anticholinergic, side effects. A significant advance has been the development of more specific H1 antagonists in which these other properties are greatly reduced. Terfenadine and astemizole were the first;1 acrivastine (Semprex - Wellcome), cetirizine (Zirtek - A&H) and loratadine (Clarityn - Schering Plough) are three newer ones. Are they better than terfenadine and astemizole?

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