Article Text

PDF
Small doses of levodopa for parkinson’s disease

Abstract

Our last full discussion of Parkinson’s disease recommended using the minimum effective dose of levodopa in combination with a peripheral dopa decarboxylase inhibitor1 - carbidopa in Sinemet (co-careldopa) and benserazide in Madopar (co-beneldopa). Combined formulations offer levodopa in various doses together with an inhibitor: Madopar 62.5 contains levodopa 50mg + benserazide 12.5mg base; low strength Sinemet, Sinemet-LS, contains levodopa 50mg + carbidopa 12.5mg. Both these preparations offer a relatively low dose but the Sinemet-LS tablet is scored and the 62.5mg tablet of Madopar Dispersible can be broken so that even lower doses can be used. This article examines when these small doses are useful.

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.