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No evidence that corticosteroids help in septic shock

Abstract

About half of all patients in shock associated with sepsis die, despite advances in intensive care and the support of failing organs. Many treatments have been tried, including high-dose corticosteroids, but evidence that any of them help is sparse. Some textbooks still recommend high-dose corticosteroids, e.g. The Oxford Textbook of Medicine, and dexamethasone is marketed in a formulation specifically for use in shock (Decadron Shock-Pak), but the data sheet for Solu-Medrone (Upjohn) now mentions septic shock as a specific contra-indication.

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