Metoclopramide (Maxolon; Primperan), has been around for over 20 years and domperidone (Motilium - Sterling Winthrop) for eight years. Both are prokinetic drugs which speed gastric emptying, increase oesophageal sphincter pressure, stimulate gut motility and in addition have a central antiemetic effect. Cisapride (Prepulsid - Janssen; Alimix - Cilag) has a similar chemical structure to metoclopramide and is intended for the reduction of oesophageal reflux and relief of symptoms caused by impaired gastrointestinal motility. The product licence has recently been extended to include treatment of non-ulcer dyspepsia.
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