Article Text

PDF
▼Nicorandil for angina
  • Relevant BNF section: 2.6.3

Abstract

Nicorandil (Ikorel - Rhône-Poulenc Rorer; Merck & Lipha) is marketed for the prevention and long-term treatment of angina pectoris. The drug, which has been used in Japan for about ten years, was introduced in the UK last year as the first of a new class of anti-anginal drug. Nicorandil combines the properties of an organic nitrate with those of a potassium-channel activator, causing dilatation of coronary arteries and arterioles, systemic resistance vessels and veins. The manufacturer claims that nicorandil is 'effective monotherapy for up to 80% of patients', that 'efficacy is sustained because haemodynamic tolerance does not occur' and that the drug 'frees patients from many of the limitations of earlier therapies'. We examine these claims.

Statistics from Altmetric.com

  • Relevant BNF section: 2.6.3

View Full Text

Footnotes

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.