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Vitamin B12 by mouth

Abstract

The small quantity of vitamin B12 in a normal diet is absorbed by a complex process involving the liberation of the vitamin from food proteins, its combination with a glycoprotein secreted by the gastric mucosa (‘intrinsic factor’), its uptake by the ileal mucosa and its transfer to the blood stream.1 Vitamin B12 in very large amounts, and probably some of that present in liver and kidney, is absorbed mainly by direct diffusion without the participation of intrinsic factor.

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