Around 1% of adults in the UK have rheumatoid arthritis (RA).1 UK national guidelines recommend that such people should receive disease-modifying anti-rheumatic drugs (DMARDs) as soon as possible after diagnosis, as earlier treatment is more effective in reducing disease progression.2,3 Also, it has been proposed that combination DMARD therapy may reduce joint damage more than single drugs.1,2,4 In the light of several recently published trials on combination therapy in early RA,5–14 here we update our recommendations on such treatment. 15,16
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