Abstract

The risk of unwanted cardiovascular effects associated with NSAIDs has been publicised in the UK in recent years by the Medicines and Healthcare products Regulatory Agency (MHRA)1^,2 and the National Prescribing Centre (NPC).3 Here we consider the evidence on cardiovascular risk in the context of other unwanted effects of NSAIDs (particularly those relating to the gastrointestinal tract and the kidneys), and offer practical advice on the use of NSAIDs in patients with cardiovascular disease.