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High-dose vitamin D for the prevention of RTI in young children

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The effect of different doses of vitamin D for prevention of wintertime respiratory tract infections (RTI) in pre-school children has been assessed in a randomised trial.1 A recent meta-analysis of 25 trials in adults and children found that vitamin D had a modest effect of preventing acute RTIs among all participants (adjusted odds ratio 0.88, 95% CI 0.81 to 0.96; number-needed-to-treat 33), with a more pronounced effect in those with low vitamin D status (baseline circulating 25-hydroxyvitamin D …

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