The article on topical application of cytotoxic drugs (July 5, 1968, p. 55) stated that demecolcine, methotrexate and 5-fluouracil had been used in concentrations ranging from 0.1% to 20%. This was in no way a recommendation, but we should like to make it clear that Ciba advise caution in the use of extemporaneously prepared ointments containing demecolcine, especially in concentrations greater than 0.5%. Lederle advise that local applications of methotrexate should contain no more than 1%. 5-Fluouracil should not be used at a concentration greater than 5%.
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.