Rifampicin (Rifadin-Lepetit; Rimactane-Ciba) is a semi-synthetic antibiotic derived from Streptomyces mediterranei which inhibits the synthesis of bacterial messenger-RNA. In vitro it is active against Gram-positive organisms and mycobacteria in low concentrations (0.0002 – 0.5 mcg/ml); and against Gram-negative organisms in higher concentrations (1 – 10 mcg/ml). Drug-resistant mutants readily emerge if rifampicin is used alone.1 It is already established as an important agent in the treatment of tuberculosis. Its usefulness in other bacterial and in viral infections is uncertain.
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