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Dizoxide for hyperinsulinism

Abstract

Diazoxide (Eudimene - A & H) was discovered during the search for a hypotensive non-diuretic analogue of chlorothiazide.1 It was found to have a hyperglycaemic effect and also lowers blood pressure, especially after intravenous administration of the sodium salt. It suppresses the insulin response to oral glucose2 and has been used to antagonise the effects of excess insulin secreted from islet-cell tumours.3 The drug has for some years been used in the US (as Hyperstat - Schering Corp.) but has only recently been marketed in Britain.

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