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Drugs and light for the prevention and treatment of neo-natal jaundice

Abstract

The enzyme system for conjugating bilirubin is often deficient in neonates, especially the immature. Unconjugated bilirubin is not excreted well, and if the concentration in plasma exceeds about 20 mg/100 ml,1 unbound unconjugated bilirubin may pass the blood-brain barrier2 and cause permanent damage - kernicterus. The treatment of jaundiced infants is aimed at preventing this damage.

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