Diabetes insipidus results from lesions of the supraoptic nuclei or the hypothalamo-hypophysial tract which limit secretion of vasopressin. Less commonly there is a renal defect, inherited predominantly by males, in which the tubules are unresponsive to vasopressin. Symptoms are thirst, polydipsia and excretion of large volumes of dilute but otherwise normal urine. These complaints are often temporary after hypophysectomy or head injury because damaged supraoptic fibres recover to secrete vasopressin. Tests described by de Wardener1 must be applied to establish the diagnosis and distinguish between diabetes insipidus and compulsive water drinking.
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.