We reviewed oxypertine (Integrin) in 1967, soon after it was introduced as a major tranquilliser.1 Structurally it is related to 5-hydroxytryptamine. Capsules containing a lower dose than the original tablets are now being marketed with claims that it is a ‘fundamental’ treatment for anxiety and that ‘it goes straight to the root of the problem and combats the disturbed brain-chemistry that underlies anxiety’. Like some other major tranquillisers, e.g. reserpine, oxypertine does lower amine levels in the central nervous system in animal preparations.
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