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Does doxycycline delay the next COPD exacerbation?

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A possible, long-term prophylactic effect of antibiotics given to patients with acute exacerbations of chronic obstructive pulmonary disease (COPD) in the outpatient setting has been investigated in a randomised controlled trial.1 Although antibiotics are recommended for some patients for the management of acute exacerbations, systematic reviews and clinical trials have shown conflicting results.2–4 Results of studies that have examined the effect of antibiotics have been inconsistent.4 There is evidence demonstrating that antibiotics result in some short-term improvement in patients who are …

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