RT Journal Article
SR Electronic
T1 Hydromet: methyldopa + hydrochlorothiazide
JF Drug and Therapeutics Bulletin
JO Drug Ther Bull
FD BMJ Publishing Group Ltd
SP 55
OP 56
DO 10.1136/dtb.2.14.55
VO 2
IS 14
YR 1964
UL http://dtb.bmj.com/content/2/14/55.abstract
AB Hydromet (MSD) is a mixture of 250 mg methyldopa with 15 mg hydrochlorothiazide in a tablet offered for the treatment of hypertension. Both drugs may lower the blood pressure when it is raised. In a double-blind trial1 a combination of the two (given in separate tablets) was found to be better than either drug alone combined with a placebo. The dose of hydrochlorothiazide was 100 mg daily and the dose of methyldopa was increased from 1 to 2 G daily after the first week.