RT Journal Article SR Electronic T1 Filling the gap between aspirin and morphine JF Drug and Therapeutics Bulletin JO Drug Ther Bull FD BMJ Publishing Group Ltd SP 45 OP 47 DO 10.1136/dtb.22.12.45 VO 22 IS 12 YR 1984 UL http://dtb.bmj.com/content/22/12/45.abstract AB What should the doctor do when pain fails to respond to ‘analgesic’ doses of aspirin or paracetamol? The cause of the pain may suggest an appropriate substitute or adjuvant remedy. Pain associated with inflammation, for instance, may respond to aspirin in ‘anti-inflammatory’ doses (4–5g daily) or to another non-steroidal anti-inflammatory drug1. Other measures include the avoidance of precipitating factors and the use of heat, ice, rest, splinting or manipulation. If anxiety or depression are contributing to pain, help with these may be more effective than a stronger analgesic.