RT Journal Article SR Electronic T1 Antimicrobial prophylaxis for orthopaedic surgery JF Drug and Therapeutics Bulletin JO Drug Ther Bull FD BMJ Publishing Group Ltd SP 43 OP 46 DO 10.1136/dtb.2001.39643 VO 39 IS 6 YR 2001 UL http://dtb.bmj.com/content/39/6/43.abstract AB Relevant BNF section: 5.1The number and range of orthopaedic procedures performed in the UK has increased over recent decades, with many more devices now being implanted to replace diseased joints, stabilise bone or correct skeletal deformities. With these advances, the number, type and complexity of potential surgical site infections have increased. Postoperative orthopaedic infections can impair the functional result of surgery, prolong hospital admission, harm patients and sometimes prove fatal.1,2 They require vigorous treatment with antibiotics and often necessitate further surgery. Here, we discuss measures for preventing surgical site infection after orthopaedic surgery, concentrating on major joint replacement and surgery for long bone fractures.