RT Journal Article SR Electronic T1 â–¼Mirtazapine - another new class of antidepressant JF Drug and Therapeutics Bulletin JO Drug Ther Bull FD BMJ Publishing Group Ltd SP 1 OP 3 DO 10.1136/dtb.1999.3711 VO 37 IS 1 YR 1999 UL http://dtb.bmj.com/content/37/1/1.abstract AB Relevant BNF section: 4.3.1â–¼Mirtazapine (Zispin-Organon) was introduced in 1997 as "the first noradrenergic and specific serotonergic antidepressant" (or 'NaSSA'). The manufacturer claims that mirtazapine is "effective in all types of depression", with "minimal serotonergic, anticholinergic and antiadrenergic side-effects", "low propensity for interactions", and lower likelihood of relapse during maintenance treatment than with amitriptyline. Is mirtazapine an advance on existing drugs?