RT Journal Article
SR Electronic
T1 Cholestyramine
JF Drug and Therapeutics Bulletin
JO Drug Ther Bull
FD BMJ Publishing Group Ltd
SP 81
OP 82
DO 10.1136/dtb.6.21.81
VO 6
IS 21
YR 1968
UL http://dtb.bmj.com/content/6/21/81.abstract
AB Cholestyramine (Cuemid - MSD) is an insoluble chloride salt of a basic anion-exchange resin. In the gut it exchanges chloride for bile-acids. The bound bile-acids cannot be reabsorbed and are excreted in the faeces. Bile-acid synthesis is probably regulated by the amount of bile-acid in the enterohepatic circulation. Cholesterol is oxidized to maintain normal levels of bile-acids, so cholestyramine, by impairing the absorption of bile-salts from the intestine, increases the rate of cholesterol oxidation and lowers the plasma cholesterol level.