RT Journal Article
SR Electronic
T1 Lithium in mania and depression
JF Drug and Therapeutics Bulletin
JO Drug Ther Bull
FD BMJ Publishing Group Ltd
SP 103
OP 104
DO 10.1136/dtb.4.26.103
VO 4
IS 26
YR 1966
UL http://dtb.bmj.com/content/4/26/103.abstract
AB In 1949 Cade1 introduced lithium into psychiatric use in Australia demonstrating its efficacy in the treatment of manic excitement. Unfortunately the drug almost immediately acquired a sinister reputation in the United States when its use as a salt substitute in cardiac patients caused a number of deaths from lithium poisoning.2 In Europe the advent of chlorpromazine and reserpine in the early 1950’s delayed the development of lithium; but in the last few years interest has revived as knowledge of fluid balance and mineral metabolism in affective disorders has increased.3