PT  - JOURNAL ARTICLE
ED  - ,
TI  - Ethacrynic acid
AID  - 10.1136/dtb.4.2.6
DP  - 1966 Jan 21
TA  - Drug and Therapeutics Bulletin
PG  - 6--8
VI  - 4
IP  - 2
4099  - http://dtb.bmj.com/content/4/2/6.short
4100  - http://dtb.bmj.com/content/4/2/6.full
SO  - Drug Ther Bull1966 Jan 21; 4
AB  - Ethacrynic acid (Edecrin - MSD), like chlorothiazide, is the product of an intensive search for substances with affinity for sulphydryl groups - a property shown in vitro that is closely linked with clinical diuretic potency. It is an aromatic oxyacetic acid which dissolves poorly in water, well in lipids and is acidic; these properties suggest that it will bind strongly to tissue and plasma proteins.