RT Journal Article
SR Electronic
T1 Ethacrynic acid
JF Drug and Therapeutics Bulletin
JO Drug Ther Bull
FD BMJ Publishing Group Ltd
SP 6
OP 8
DO 10.1136/dtb.4.2.6
VO 4
IS 2
YR 1966
UL http://dtb.bmj.com/content/4/2/6.abstract
AB Ethacrynic acid (Edecrin - MSD), like chlorothiazide, is the product of an intensive search for substances with affinity for sulphydryl groups - a property shown in vitro that is closely linked with clinical diuretic potency. It is an aromatic oxyacetic acid which dissolves poorly in water, well in lipids and is acidic; these properties suggest that it will bind strongly to tissue and plasma proteins.